XL388 - CAS# 1251156-08-7 Catalog No.:M9702-10 Imidazoline receptors associated with noradrenergic

Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine

Ringseis R

Formula: C24H28N4O3

Chemical Name: 1-tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3

Smiles: CC(C)OC(=O)[C@H](C)N[P@](=O)(CO[C@H](C)CN1C=NC2=C(N)N=CN=C12)OC1=CC=CC=C1

XL388 - CAS# 1251156-08-7 Catalog No.:M9702-10 Imidazoline receptors associated with noradrenergicXL388 is a Novel Class of Highly Potent, Selective, ATP Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR). XL388 inhibited cellular phosphorylation of mTOR complex 1 (p p70S6K, pS6, and p 4E BP1) and mTOR complex 2 (pAKT (S473)) substrates. XL388 displayed good pharmacokinetics and oral exposure in multiple species with moderate bioavailability. Oral administration of XL388 to athymic nude mice implanted with